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Asymmetric Total Synthesis of Clionastatins A and B Wei Ju CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

24.08.2021 · Total Synthesis of Clionastatins A and B. Clionastatins A and B (pictured, X = H for clionastatin A, X = Cl for clionastatin B) are polychlorinated steroids that were first isolated from the sponge Cliona nigricans. Their proposed structure has been based on NMR spectroscopic data, and no X-ray crystallographic structures have been available.

Oct 19, 2021 · Gui and co-workers report the first total synthesis of (+)-clionastatins A and B, a novel class of polyhalogenated steroids isolated from a natural source. The synthesis led to revision of the originally proposed structures. # Comment. Acyl telluride C was accessed in three steps from enone A.

18.11.2020 · Interconversion of dankasterone B and periconiastone A was observed. Abstract We describe herein the assembly of the cis -decalin framework through radical cyclization initiated by metal-catalyzed hydrogen atom transfer (MHAT), further applied it in the asymmetric synthesis of dankasterones A and B and periconiastone A. Position-selective C−H oxygenation allowed for …

Asymmetric Total Synthesis of Clionastatins A and B Wei Ju, ‡ Xudong Wang, ‡ Hailong Tian and Jinghan Gui* CAS Key Laboratory of Synthetic Chemistry of Natur al Substances, Center for ...

Asymmetric Total Synthesis of Clionastatins A and B Regulating ProcurementUnderstanding the Ends and Means of Public Procurement Regulation 10.33774/chemrxiv-2021-q9rcr

Asymmetric Total Synthesis of Clionastatins A and B J Am Chem Soc. 2021 Aug 25;143(33):13016-13021. doi: 10.1021/jacs.1c07511. Epub 2021 Aug 16. Authors Wei Ju 1 , Xudong Wang 1 , Hailong Tian 1 , Jinghan Gui 1 Affiliation 1 CAS Key Laboratory of Synthetic ...

Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by means of a convergent ...

The clionastatins are the first polyhalogenated steroids to have been isolated from a natural source (either marine or terrestrial). Notably, ...

Asymmetric Total Synthesis of Clionastatins A and B J Am Chem Soc. 2021 Aug 25;143(33):13016-13021. doi: 10.1021/jacs.1c07511. Epub 2021 Aug 16. Authors ...

Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by means ...

22.11.2021 · Asymmetric construction of dithiodiketopiperazines on otherwise achiral scaffolds remains a pivotal synthetic challenge encountered in many biologically significant natural products. Herein, we report the first total syntheses of (−)-glionitrin A/B and revise the absolute configurations. Emerging from the study is a novel oxidative sulfenylation of triketopiperazines …

16.08.2021 · Asymmetric Total Synthesis of Clionastatins A and B. Journal of the American Chemical Society ( IF 15.419 ) Pub Date : 2021-08-16 , DOI: 10.1021/jacs.1c07511. Wei Ju, Xudong Wang, Hailong Tian, Jinghan Gui. Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by ...

Request PDF | Asymmetric Total Synthesis of Clionastatins A and B | Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished ...

Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by means ...

Asymmetric Total Synthesis of Clionastatins A and B Wei Ju, ‡ Xudong Wang, ‡ Hailong Tian and Jinghan Gui* CAS Key Laboratory of Synthetic Chemistry of Natur al Substances, Center for ...

Aug 16, 2021 · Asymmetric Total Synthesis of Clionastatins A and B. Journal: Journal of the American Chemical Society Published: 2021-08-16 DOI: 10.1021/jacs.1c07511 Affiliations: 2 ...

Key features of the synthesis are the highly syn-selective Evans aldol reaction, ring-closing metathesis, highly diastereoselective dihydroxylation and acid- ...

Clionastatins A and B (pictured, X = H for clionastatin A, X = Cl for clionastatin B) are polychlorinated steroids that were first isolated ...

Asymmetric #TotalSynthesis of Clionastatins A and B by Wei Ju, Xudong Wang, Hailong Tian, and. @Jinghan_Gui. at the Shanghai Institute of ...

Asymmetric Total Synthesis of Clionastatins A and B Wei Ju CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Jul 12, 2021 · Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by means of a convergent, radical fragment coupling approach. Key features of the synthesis include an Ireland–Claisen rearrangement to introduce the C5 stereocenter (which was ultimately transferred to the C10 quaternary stereocenter of the clionastatins via a ...

Asymmetric Total Synthesis of Clionastatins A and B. J. Am. Chem. Soc. 2021, 143, 13016–13021, DOI: 10.1021/jacs.1c07511.

12.07.2021 · Herein we report the first total synthesis of polychlorinated steroids clionastatins A and B, which was accomplished asymmetrically by means of a convergent, radical fragment coupling approach. Key features of the synthesis include an Ireland–Claisen rearrangement to introduce the C5 stereocenter (which was ultimately transferred to the C10 quaternary …