Department of Medicinal Chemistry
sop.washington.edu › department-of-medicinal-Nov 03, 2020 · Medicinal Chemistry is a discipline with a traditional focus on organic synthetic chemistry with the broad goals of drug discovery and optimization. The Department of Medicinal Chemistry has always departed somewhat from this tradition given the focus of many of its faculty on the research areas of mechanistic drug metabolism, toxicology, and ...
Rational Design and Synthesis of Novel Dual PROTACs for ...
https://pubmed.ncbi.nlm.nih.gov/34038131J Med Chem. 2021 Jun 10;64(11):7839-7852. doi: 10.1021/acs.jmedchem.1c00649. Epub 2021 May 26. Authors Mengzhu Zheng 1 , Junfeng Huo 1 , Xiaoxia Gu 1 , Yali Wang 2 , Canrong Wu 1 , Qingzhe Zhang 1 , Wang Wang 2 , Yang Liu 2 , Yu Liu 1 , Xuechen Zhou 1 , …
Journal of Medicinal Chemistry - Wikipedia
https://en.wikipedia.org/wiki/Journal_of_Medicinal_ChemistryThe Journal of Medicinal Chemistry is a peer-reviewed medical journal covering research in medicinal chemistry. It is published by the American Chemical Society. It was established in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry and obtained its current name in 1963. Portoghese had served as editor-in-chief from 1972-2011. In 2012, Gunda I. Georg (University of Minnesota) and Shaomeng Wang (University of Michigan) succeeded Philip S. Portoghese (Unive…
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that ...
https://pubmed.ncbi.nlm.nih.gov/33370104J Med Chem. 2021 Jan 14;64(1):677-694. doi: 10.1021/acs.jmedchem.0c01698. Epub 2020 Dec 28. Authors Chunjian Liu 1 , James Lin 1 , Charles Langevine 1 , Daniel Smith 2 , Jianqing Li 2 , John S Tokarski 3 , Javed Khan 3 , Max Ruzanov 3 , Joann Strnad 4 , Adriana Zupa-Fernandez 4 , Lihong Cheng 4 ...
Journal of Medicinal Chemistry | Vol 64, No 24
pubs.acs.org › toc › jmcmarJournal of Medicinal Chemistry 2021, 64, 21, 15787-15798 (Article) Publication Date (Web): October 27, 2021. Abstract. Full text. PDF. ABSTRACT. Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models.