What is in Our Kit? An Analysis of Building Blocks Used in ...
pubs.acs.org › doi › 10Nov 22, 2021 · Building blocks are the molecular foundations for drug molecule design. The building block is one of the determining factors of final compound qualities in any given medicinal chemistry campaign. Herein, we describe our analysis of the building blocks used in parallel library synthesis at AbbVie. The results gave insights into the synthetic tractability and accessibilities of building blocks ...
ACS Medicinal Chemistry Letters
https://pubs.acs.org/journal/amclct10.11.2015 · New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science. ACS Medicinal Chemistry Letters, ACS Pharmacology & Translational Science, and Journal of Medicinal Chemistry welcome submissions to this joint Virtual Special Issue. Submission deadline: July 31, 2022. Read the Editorial to learn more
Discovery of Milvexian, a High-Affinity, Orally Bioavailable ...
pubs.acs.org › doi › 10Factor XIa (FXIa) is an enzyme in the coagulation cascade thought to amplify thrombin generation but has a limited role in hemostasis. From preclinical models and human genetics, an inhibitor of FXIa has the potential to be an antithrombotic agent with superior efficacy and safety. Reversible and irreversible inhibitors of FXIa have demonstrated excellent antithrombotic efficacy without ...
Asian Journal of Pharmaceutical Analysis and Medicinal ...
ajpamc.comWelcome to AJPAMC. Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry. The Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry (AJPAMC) is an online Journal and international peer review Quarterly, scientific and professional journal emphasizing quality pharmaceutical discoveries and innovations.AJPAMC provides a medium for publication of novel …
Journal of Medicinal Chemistry: List of issues
https://pubs.acs.org/loi/jmcmarJournal of Medicinal Chemistry (1963 - onwards) Journal of Medicinal and Pharmaceutical Chemistry (1959 - 1962) CURRENT ISSUE; VIEW ALL ISSUES; Get e-Alerts. CURRENT ISSUE; VIEW ALL ISSUES; 2020s; 2010s; 2000s; 1990s; 1980s; 1970s; 1960s; 1950s; 2021; 2020; Archive of 2021 Online Issues. December 23, 2021 Vol. 64 Issue 24.