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30.12.2021 · Immunomodulatory drugs are a class of drugs approved for the treatment of multiple myeloma. These compounds exert their clinical effects by inducing interactions between the CRL4CRBN E3 ubiquitin ligase and a C2H2 zinc finger degron motif, resulting in degradation of degron-containing targets. However, although many cellular proteins feature the degron motif, …

Chemical biology, medicinal chemistry, structure-guided drug design, protein biochemistry, structural biology, cancer biology, protein kinases, ...

Editor-in-Chief of Journal of Medicinal Chemistry, University of Michigan. Selected Most Cited Articles. Kelly Chibale. University of Cape Town. Selected Highly Prolific Authors. Selected Most Read Articles. Selected Highly Read ACS Editors' Choice Articles. Gary Look, Look Biophama Consulting. Award Winners.

Journal of Medicinal Chemistry 2021, 64, 21, 15787-15798 (Article) Publication Date (Web): October 27, 2021. Abstract. Full text. PDF. ABSTRACT. Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models.

Jun 29, 2021 · The Journal of Medicinal Chemistry is the most prestigious in our field. I am excited to play a small part in continuing this tradition and steering the journal forward. I see serving on the Early Career Board as an opportunity to reach out to new talent in the field, bring them into the collection of amazing scientists who publish in the journal and to increase collaborations with the ACS ...

2020 Journal Citation Reports (Clarivate Analytics): 192/297 (Biochemistry & Molecular Biology)37/63 (Chemistry, Medicinal). Online ISSN:1439-7633.

The European Journal of Medicinal Chemistry is a monthly peer - reviewed scientific journal covering medicinal chemistry and published by Elsevier. It was Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry especially synthetic organic chemistry and pharmacology Anti - Cancer Agents in Medicinal Chemistry is a peer - …

Dec 30, 2021 · In 1963, the ACS changed the name of the Journal to the Journal of Medicinal Chemistry (JMC), and by 1970, the journal had doubled in size and transitioned to a monthly publication. Alfred Burger wrote a wonderful commentary on the birth of JMC in 1991, (2) and I encourage you all to read the fascinating road that led to the JMC as we know it ...

18.11.2021 · The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair. Emerging evidence suggests that dysregulation of AlkB demethylases may underlie the pathogenesis of several …

Dec 28, 2021 · CREB (cyclic-AMP responsive element binding protein) binding protein (CBP) is a potential target for prostate cancer treatment. Herein, we report the structural optimization of a series of 1-(indolizin-3-yl)ethan-1-one compounds as new selective CBP bromodomain inhibitors, aiming to improve cellular potency and metabolic stability. This process led to compound 9g (Y08284), which possesses good ...

Cellular senescence, a process that arrests the cell cycle, is a cellular response mechanism for various stresses and is implicated in aging and various age-related diseases. However, the understanding of senescence in living organisms is insufficient, largely due to the scarcity of sensitive tools for the detection of cellular senescence in vivo. Herein, we describe the development of a self ...

The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging ...

ACS Medicinal Chemistry Letters , ACS Pharmacology & Translational Science , and Journal of Medicinal Chemistry welcome submissions to this joint Virtual ...

Journal of Medicinal Chemistry 1986, 29, 10, 2024-2028 (Article) Publication Date (Print): October 1, 1986. First Page. PDF. Stereochemical studies on medicinal agents. 30. Investigation of 4- (3-hydroxyphenyl)-4-methylpipecolic acid as a conformationally restricted mimic of the tyrosyl residue of leucine-enkephalinamide. Elizabeth E. Sugg.

Bioorganic & Medicinal Chemistry publishes complete accounts of research of outstanding significance and timeliness on all aspects of molecular interactions at the interface of chemistry and biology, together with critical review articles. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing …

Journal of Medicinal Chemistry 2021, 64, 21, 15787-15798 (Article) Publication Date (Web): October 27, 2021. Abstract. Full text. PDF. ABSTRACT. Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models.

Dec 27, 2021 · Nowadays, the simultaneous inhibition of two or more pathways plays an increasingly important role in cancer treatment due to the complex and diverse pathogenesis of cancer, and the combination of the cyclin-dependent kinase 6 (CDK6) inhibitor and PIM1 inhibitor was found to generate synergistic effects in acute myeloid leukemia (AML) treatment. Therefore, we discovered a novel lead 1 ...

Journal Scope. The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.. Some specific areas that are appropriate include the following: Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled …

The European Journal of Medicinal Chemistry is a global journal that publishes studies on the main aspects of medicinal chemistry. It provides a medium for publication of original research papers and also welcomes critical review papers. A typical paper would report on the design (with or without the support of computational methods), organic ...

Asian Journal of Chemistry, a Multidisciplinary Chemistry Journal is an Peer Reviewed International Journal and publishes from India. The journal has been ...

We present three case studies of Twitter bots for cheminformatics: retrosynthetic analysis, 3D molecule viewer, and 2D chemical structure ...

American Journal of Medicinal Chemistry (ISSN 2733-2519) All the work at Science Repository is licensed under a Creative Commons Attribution 4.0 International License. Authors at Science Repository retain copyright to their work and allow others to copy, distribute, transmit, and adapt their work, provided proper attribution is given.

Journal of Medicinal Chemistry (1963 - onwards) Journal of Medicinal and Pharmaceutical Chemistry (1959 - 1962) CURRENT ISSUE; VIEW ALL ISSUES; Get e-Alerts. CURRENT ISSUE; VIEW ALL ISSUES; 2020s; 2010s; 2000s; 1990s; 1980s; 1970s; 1960s; 1950s; 2021; 2020;