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Ionizing radiation can exert a number of adverse toxicological effects on many tissues in the body by ionizing and subsequently altering the DNA in the nucleus ...

24.04.2020 · Mechanism of Sterilization by Ionizing Radiations. When ionizing radiation collides with particles, they produce electrons (e −) and other reactive molecules such as hydroxyl radicals (•OH), and hydride radicals (H•). Each of these reactive molecules is capable of degrading and altering biopolymers such as DNA and protein.

The source of IR is a class of unstable radionuclides (radioisotopes) that emit high-energy particles which are capable of displacing atomic electrons, ...

Woodward GE. The effect of ultra-violet, radium and X-ray radiation on glutathione in pure solution. Biochem J. 1933; 27 (5):1411–1414. [PMC free article] [] [Google Scholar]BARRON ESG, DICKMAN S, et al. Studies on the mechanism of action of ionizing radiations; inhibition of enzymes by X-rays.

Ionizing radiation (IR) is a common therapeutic agent in cancer therapy. It damages normal tissue and causes side effects including dermatitis and mucositis. Here we use the feather follicle as a model to investigate the mechanism of IR-induced tissue damage, because any …

gating the mechanisms underlying cancer risk from exposure to ionizing radiation have concentrated on low- dose exposures, typically of 0.1 Gy.

Jun 29, 2021 · Ionizing radiation is a form of energy that acts by removing electrons from atoms and molecules of materials that include air, water, and living tissue. Ionizing radiation can travel unseen and pass through these materials. It is on the right side of the electromagnetic spectrum in the figure below.

In the direct action, the radiation hits the DNA molecule directly, disrupting the molecular structure. Such structural change leads to cell damage or even cell ...

Indirectly ionizing radiation is electrically neutral and does not interact strongly with matter, therefore the bulk of the ionization effects are due to secondary ionization. Even though photons are electrically neutral, they can ionize atoms indirectly through the photoelectric effect and the Compton effect. Either of those interac…

10.07.2014 · Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated series of events that are amplified by endogenous signaling and culminating in oxidative damage to DNA, lipids, proteins, and many metabolites. Despite the global impact of IR, the molecular mechanisms underlying tissue damage reveal that many biomolecules are …

It is well established that DNA damage is the main mechanism associated with ionizing radiation tumorigenicity; however, ionizing radiation also causes major aberrations in the cellular epigenome, including alterations in DNA methylation, histone modifications, and chromatin accessibility.

Jump to navigation Jump to search. Harmful high-frequency radiation. Ionizing radiation (or ionising radiation ), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. The particles generally travel at a speed that is 99% of the that of light, and the electromagnetic waves are on the high-energy portion of the electromagnetic spectrum .

Dissecting the molecular mechanism of ionizing radiation-induced tissue damage in the feather follicle. Ionizing radiation (IR) is a common therapeutic agent in cancer therapy. It damages normal tissue and causes side effects including dermatitis and mucositis. Here we use the feather follicle as a model to investigate the mechanism of IR-induced tissue damage, because any perturbation of feather grow ….

Ionizing radiation (IR)-induced systemic effects arise usually from a local exposure of an organ or part of the body. This stress induces a variety of responses ...

IR induces the expression of many cytokines, which may have a local or systematic impact [11]–[14]. Inflammation, and subsequent tissue fibrosis ...

This ToF enhancement is determined by the PET system's coincidence time resolution (CTR). With a goal to drastically improve CTR over the conventional scintillation-based detection approach used in all existing PET systems, I have explored a new mechanism of ionizing radiation detection using ionization-induced optical property modulations.

Evidence indicates that damage to the DNA is what causes cell death, mutation, and carcinogenesis. The mechanism by which the damage occurs can happen via one ...