Structure-based drug design strategies in medicinal chemistry
pubmed.ncbi.nlm.nih.gov › 19754394A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This review summarizes current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as challenges, along with the value of ...
Organic Carbamates in Drug Design and Medicinal Chemistry
www.ncbi.nlm.nih.gov › pmc › articlesApr 09, 2015 · The carbamate group is a key structuralmotif in many approveddrugs and prodrugs. There is an increasing use of carbamates in medicinalchemistry and many derivatives are specifically designed to make drug–targetinteractions through their carbamate moiety. In this Perspective,we present properties and stabilities of carbamates, reagents andchemical methodologies for the synthesis of carbamates, and recentapplications of carbamates in drug design and medicinal chemistry.