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Dec 16, 2021 · Targovax has a diversified immune activator portfolio and aims to become a leader in this area. The Company’s lead product, ONCOS-102, is an oncolytic adenovirus armed with an immune-stimulating transgene, which is currently being investigated in four ongoing clinical trials.

ONCOS-102 · Norske Targovax inngår immunterapi-samarbeid med legemiddelgigant · Ny studie: Targovax melder om økt immunaktivering og overlevelse blant ...

A Pilot Study of Sequential ONCOS-102, an Engineered Oncolytic Adenovirus Expressing GMCSF, and Pembrolizumab in Patients With Advanced or Unresectable Melanoma ...

The median overall survival (mOS) was 25.0 months in the first-line group of patients treated with ONCOS-102 plus chemotherapy, compared with 13.5 months mOS for the chemotherapy-only control group Oslo, Norway, 20 December 2021 – Targovax ASA (OSE: TRVX), a clinical-stage immuno-oncology comp...

Dec 20, 2021 · Targovax ASA (OSE: TRVX), a clinical-stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors, today announces mOS of 25.0 months for treatment with ONCOS-102 in combination with Standard of Care (SoC) chemotherapy in malignant pleural mesothelioma (MPM) in the subgroup of patients receiving therapy in the first-line setting.

Dec 20, 2021 · The median overall survival (mOS) was 25.0 months in the first-line group of patients treated with ONCOS-102 plus chemotherapy, compared with 13.5 months mOS for the chemotherapy-only control ...

Økt behandling med Oncos-102 har ikke økt effekten betydelig og vi ser heller ikke CR. Lykke til med å hente penger for MESOTHELIOMA studien ...

ONCOS-102 is a serotype 5 adenovirus that has a genetically modified fiber with a serotype 3 knob for enhanced gene delivery to cancer cells [13]. It is armed ...

24.11.2020 · ONCOS-102 is currently being tested in mesothelioma, melanoma and colorectal cancer and has already shown promising clinical results both as monotherapy and in combination with chemotherapy, and a checkpoint inhibitor. IR contact. Renate Birkeli. Investor Relations.

Medikamentet ONCOS-102 er et modifisert adenovirus som skal reaktivere immuncellene til igjen å kunne angripe kreften. I studien vil du behandles med en enkelt injeksjon med en lav dose cyclofosfamid, etterfulgt av fire injeksjoner med ONCOS-102, og deretter 8 doser pembrolizumab i kombinasjon med ONCOS-102.

Dec 20, 2021 · Importantly, we have confirmed that ONCOS-102 is active and effective in highly different types of solid tumors in both early and late lines of therapy. Based on the encouraging patient outcomes and deep mechanistic analysis from the phase 1/2 program, we are currently designing and preparing for the next phase in ONCOS-102 clinical development."

28.12.2016 · A Pilot Study of Sequential ONCOS-102, an Engineered Oncolytic Adenovirus Expressing GMCSF, and Pembrolizumab in Patients With Advanced or Unresectable Melanoma Progressing After Programmed Cell Death Protein 1 (PD1) Blockade - Full Text View.

Dec 20, 2021 · Importantly, we have confirmed that ONCOS-102 is active and effective in highly different types of solid tumors in both early and late lines of therapy. Based on the encouraging patient outcomes and deep mechanistic analysis from the phase 1/2 program, we are currently designing and preparing for the next phase in ONCOS-102 clinical development."

Medikamentet ONCOS-102 er et modifisert adenovirus som skal reaktivere immuncellene til igjen å kunne angripe kreften. I studien vil du behandles med en ...

ONCOS-102 (Ad5/3-D24-GMCSF), (developed by Oncos Therapeutics) is an oncolytic adenovirus previously described as CGTG-102. It is currently in orphan drug status for soft tissue sarcomas.

ONCOS-102 is a oncolytic adenovirus administered by intratumoral injection that is also being tested in mesothelioma and colorectal cancer as ...

Dec 20, 2021 · At the 30-month follow-up, mOS was 25.0 months for the subgroup of randomized, first-line ONCOS-102-treated patients (n=8). This is a clear improvement over the mOS of 13.5 months observed in the ...

The ONCOS-102 treatment induces broad and powerful immune activation in MPM, far beyond what is achieved with SoC alone. Importantly, this immune activation is ...

A pilot study of engineered adenovirus ONCOS-102 in combination with pembrolizumab in checkpoint inhibitor refractory advanced or unresectable melanoma.