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The first total synthesis of Gardneria oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from d-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, and (3) an ...

The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first total synthesis of kalimantacin A, in which three fragments are prepared and then united via Sonogashira and amide couplings. The …

May 29, 2020 · Eur. J. 26, 1166–1195 (2020 ... New, abridged pathway to Masamune’s “southern hemisphere” intermediate for the total synthesis of bryostatin 7. Org. Lett ...

The asymmetric total synthesis of (-)-guignardones A ( 2 ) and B ( 1 ) has been ... Org Lett. 2020 Feb 21;22(4):1644-1647. doi: 10.1021/acs.orglett.0c00241. Epub 2020 Feb 10. Authors Zhiming Yan 1 , Chunbo Zhao 1 , Jianxian Gong 1 , Zhen Yang 1 2 Affiliations ...

Leonuketal is an 8,9-seco-labdane terpenoid with a unique tetracyclic structure, owing to a diversity-generating biosynthetic C–C bond ...

We disclose herein the first total synthesis of amphirionin-2 and ... (b) M. M. Zanardi , M. O. Marcarino and A. M. Sarotti , Org. Lett., 2020, ...

The efficient total synthesis of lycojaponicumin A (1) has been accomplished for the first time.The remarkable features of this novel strategy include the following: (1) rapid construction of tricyclic intermediate 4 through a regio- and stereoselective semipinacol ring expansion, which simplified the construction of rings A and B of 1; (2) the subsequent regio- and stereoselective formation ...

The first total synthesis of Gardneria oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from d-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, …

Kortet, S., Claraz, A., & Pihko, P. M. (2020). Catalytic Enantioselective Total Synthesis of (+)–Lycoperdic Acid. Organic Letters, 22(8), ...

“The Total Synthesis of Ent-Plagiochianin B” Jackson III, Richard K.; Wood, John L. Organic Letters 2021, 23, 1243-1246. DOI: 10.1021/acs.orglett.0c04219.

Total Synthesis of (±)-Leonuketal. Org Lett. 2020 Nov 6;22(21):8735-8740. doi: 10.1021/acs.orglett.0c03364. Epub 2020 Oct 21.

04.01.2021 · Total Synthesis of Lyconesidine B, a Lycopodium Alkaloid with an Oxygenated, Amine-Type Fawcettimine Core, Tomohiro Kurose, Chihiro Tsukano, Takeshi Nanjo, Yoshiji Takemoto, Org. Lett. 2020 .

Dander,† and Neil K. Garg. Org. Lett. 2020, 22, 1–5. 114. Total Synthesis as a Vehicle for Collaboration.

May 21, 2020 · The structure of our total-synthesized leontopodioside A was confirmed by 1 H NMR, 13 C NMR, 1 H– 1 H COSY, HMBC, and HSQC, and the data matched with those reported . To the best of our knowledge, this is the first total synthesis of leontopodioside A so far . Download : Download high-res image (328KB) Download : Download full-size image

Synthesis of Southern Fragment

We report a unified total synthesis of five bufadienolides: bufalin ( 1 ), bufogenin B ( 2 ), bufotalin ( 3 ... Org Lett. 2020 Nov 6;22 ... 10.1021/acs.orglett.0c03251. Epub 2020 Oct 26. Authors Shinsuke Shimizu 1 , Koichi Hagiwara 1 , Hiroaki Itoh 1 , Masayuki Inoue 1 Affiliation 1 Graduate School of ...

Total Synthesis of Thromboxane B2 via a Key Bicyclic Enal Intermediate. C. Jing, V. K. Aggarwal. Org. Lett., 2020, 22, 6505–6509. doi.

Feb 02, 2021 · Therefore, these compounds can be expected to be promising drug leads for neurodegenerative diseases such as Alzheimer's disease. So far, we reported the first total synthesis of neovibsanin B (3), which showed to induce neurite outgrowth by enhancing the nerve growth factor (NFG) activity , [3](a).

2.0(4,8)]undecan-10-one core of daphniphyllum alkaloid calyciphylline A using a Pd-catalyzed enolate alkenylation. Org. Lett. 7, 5461–5464 (2005) ...

Cite this: Org. Lett. 2020, 22, 16, 6349–6353. Publication Date (Web): August 10, 2020. ... Herein, we report the first total synthesis of kalimantacin A, in which ...