Total Synthesis of (-)-Gardmultimine A
https://pubmed.ncbi.nlm.nih.gov/32096647The first total synthesis of Gardneria oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from d-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, …
Total Synthesis of Fawcettimine-Type Alkaloid ...
pubmed.ncbi.nlm.nih.gov › 32330061The efficient total synthesis of lycojaponicumin A (1) has been accomplished for the first time.The remarkable features of this novel strategy include the following: (1) rapid construction of tricyclic intermediate 4 through a regio- and stereoselective semipinacol ring expansion, which simplified the construction of rings A and B of 1; (2) the subsequent regio- and stereoselective formation ...
Total Synthesis of (-)-Gardmultimine A
pubmed.ncbi.nlm.nih.gov › 32096647The first total synthesis of Gardneria oxindole alkaloid (-)-gardmultimine A has been achieved in 19 steps from d-tryptophan in a fully stereocontrolled manner. This synthesis features (1) an Ir-catalyzed regioselective C-H borylation/oxidation sequence to introduce the C12 methoxyl group, (2) a stereocontrolled oxidative rearrangement of indole to construct the spirooxindole motif, and (3) an ...