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Some alkylating agents are active under conditions present in cells; and the same mechanism that makes them toxic allows them to be used as anti-cancer drugs. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act nonspecifically.

alkylating agent, any highly reactive drug that binds to certain chemical groups (phosphate, amino, sulfhydryl, hydroxyl, and imidazole groups) commonly ...

Nucleophilic alkylating agents deliver the equivalent of an alkyl anion (carbanion). The formal "alkyl anion" attacks an electrophile, forming a new covalent bond between the alkyl group and the electrophile. The counterion, which is a cation such as lithium, can be removed and washed away in the work-up. Examples include the use of organometallic compounds such as Grignard (organomagnes…

Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell ...

Alkylating agents are effective during every phase of the life cycle of a cancer cell, which means they are effective for treating a wide range of cancers. They are most effective for treating slow-growing cancers such as leukemia and solid tumors, but are also used in the treatment of breast, lung, ovarian, and prostate cancers; lymphomas, myelomas, and sarcomas; and Hodgkin's …

Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby ...

Alkylating agents are capable of forming from strong electrophiles usually via a carbonium ion or carbon radical. These electrophilic compounds naturally seek out nucleophilic atoms and functional groups to form their covalent bonds. Nucleophilic functional groups include phosphate, amino, sulfhydryl, carboxyl, and hydroxyl groups, among mothers.

Also called cytotoxic agents or antineoplastic drugs, alkylating agents are types of chemotherapeutic drugs. They treat certain forms of cancer ...

Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis. Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links within the DNA chain and thereby resulting in cytotoxic, mutagenic, and carcinogenic effects.

A type of drug that is used in the treatment of cancer. It interferes with the cell's DNA and inhibits cancer cell growth. Search NCI's Dictionary of Cancer ...

27.10.2021 · Alkylating agents are a class of drugs among the most commonly used in chemotherapy, either alone or in combination with other therapies. This is due to the fact that they have a long track record ...

Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis. Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in …

Classical alkylating agents[edit] · Cyclophosphamide · Chlormethine · Uramustine · Melphalan · Chlorambucil · Ifosfamide · Bendamustine.

Alkylating agents were one of the first classes of drugs to be used against cancer. There are five traditional categories of alkylating agents: Nitrogen mustards (eg, bendamustine, chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan) Nitrosoureas (eg, carmustine, lomustine, streptozocin) Alkyl sulfonates (eg, busulfan)

Alkylating agents (al-ka-LAYT-ing AY-jints) are a family of anticancer drugs that interfere with cell's DNA and inhibit cancer cell growth.

Mar 10, 2015 · Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis. Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links within the DNA chain and thereby resulting in cytotoxic, mutagenic, and carcinogenic effects.

Alkylating agents act by cross-linking strands of DNA, particularly at the N-7 position of guanine. They are nonspecific for cell cycle phase and are thus active during most parts of the cell cycle. Alkylating agents in the classic family include nitrogen mustard, cyclophosphamide, chlorambucil, melphalan, busulfan, and ifosfamide.

The alkylating agents are compounds that react with electron-rich atoms in biologic molecules to form covalent bonds. Traditionally, these agents are divided into two types: those that react directly with biologic molecules and those that form a reactive intermediate, which then reacts with the biologic molecules.

Alkylating agents prevent cell division primarily by cross-linking strands of DNA. Because of continued synthesis of other cell constituents, such as RNA and protein, growth is unbalanced and the cell dies. Activity of alkylating agents does not depend on DNA synthesis in the target cells.

The alkylating agents were the first nonhormonal drugs to be used effectively in the treatment of cancer, and the story behind the recognition of the antitumor effects of these compounds is a remarkable one. During World War I, toxic gases were used as military weapons. The most devastating of these gases was sulfur mustard (Figure 51-1). The compound was used as a …

Alkylating agents prevent cell division primarily by cross-linking strands of DNA. Because of continued synthesis of other cell constituents, such as RNA and ...

Alkylating agents act by cross-linking strands of DNA, particularly at the N-7 position of guanine. They are nonspecific for cell cycle phase and are thus active during most parts of the cell cycle. Alkylating agents in the classic family include nitrogen mustard, cyclophosphamide, chlorambucil, melphalan, busulfan, and ifosfamide.