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Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from ...

Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow-derived mesenchymal stem cells Ann Hematol . 2011 Jul;90(7):777-89. doi: 10.1007/s00277-010-1141-8.

Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow-derived mesenchymal stem cells. The adverse effects of melphalan and cyclophosphamide on hematopoietic stem cells are well-known; however, the effects on the mesenchymal stem cells (MSCs) residing in the bone marrow are less well characterised.

Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and ...

An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA. ... The alkyl group is attached ...

Oct 27, 2021 · Also called cytotoxic agents or antineoplastic drugs, alkylating agents are types of chemotherapeutic drugs. They treat certain forms of cancer by stopping tumor DNA from dividing and replicating....

Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby ...

Alkylating agents are most widely used anticancer drugs and are major components of combination chemotherapy [14]. These are small molecules that can ...

27.10.2021 · Alkylating agents are a class of drugs among the most commonly used in chemotherapy, either alone or in combination with other therapies. This is due to the fact that they have a long track record ...

Alkylating agents are just one type of chemotherapeutic class considered in anticancer treatment. There are several subtypes and related drugs ...

Alkylating agents are effective during every phase of the life cycle of a cancer cell, which means they are effective for treating a wide range of cancers. They are most effective for treating slow-growing cancers such as leukemia and solid tumors, but are also used in the treatment of breast, lung, ovarian, and prostate cancers; lymphomas, myelomas, and sarcomas; and Hodgkin's …

Alkylating agents were one of the first classes of drugs to be used against cancer. There are five traditional categories of alkylating agents: Nitrogen mustards (eg, bendamustine, chlorambucil, cyclophosphamide, ifosfamide, mechlorethamine, melphalan) Nitrosoureas (eg, carmustine, lomustine, streptozocin) Alkyl sulfonates (eg, busulfan)

The alkylating agents are compounds that react with electron-rich atoms in biologic molecules to form covalent bonds. Traditionally, these agents are divided into two types: those that react directly with biologic molecules and those that form a reactive intermediate, which then reacts with the biologic molecules.

Alkylating agents were among the first anti-cancer drugs and are the most commonly used agents in chemotherapy today. Alkylating agents act directly on DNA, ...

Alkylating agents are a class of antineoplastic or anticancer drugs which act by inhibiting the transcription of DNA into RNA and thereby stopping the protein synthesis. Alkylating agents substitute alkyl groups for hydrogen atoms on DNA, resulting in the formation of cross links within the DNA chain and thereby resulting in cytotoxic, mutagenic, and carcinogenic effects.

Alkylating agents are capable of forming from strong electrophiles usually via a carbonium ion or carbon radical. These electrophilic compounds naturally seek out nucleophilic atoms and functional groups to form their covalent bonds. Nucleophilic functional groups include phosphate, amino, sulfhydryl, carboxyl, and hydroxyl groups, among mothers.

Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell cycle ...