Total Synthesis of the Potent and Broad-Spectrum Antibiotics ...
pubs.acs.org › doi › 10The complex and intriguing structures of the antibiotics amycolamicin and kibdelomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics.
Total Synthesis of (−)-Maximiscin | Journal of the American ...
pubs.acs.org › doi › 10A short, enantioselective synthesis of (−)-maximiscin, a structurally intriguing metabolite of mixed biosynthetic origin, is reported. A retrosynthetic analysis predicated on maximizing ideality and efficiency led to several unusual disconnections and tactics. Formation of the central highly oxidized pyridone ring through a convergent coupling at the end of the synthesis simplified the route ...