Journal of Chemical Information and Modeling
https://pubs.acs.org/journal/jcisd8Call for Papers. From Reaction Informatics to Chemical Space. Submissions are now open for the latest special issue from Journal of Chemical Information and Modeling.With this JCIM special issue on reaction informatics and chemical space, we would like to highlight the achievements of recent years, showcase current research, and motivate scientists in academia and industry …
Journal of Medicinal Chemistry | Vol 65, No 2
pubs.acs.org › toc › jmcmarJournal of Medicinal Chemistry 2021, 64, 21, 15787-15798 (Article) Publication Date (Web): October 27, 2021. Abstract. Full text. PDF. ABSTRACT. Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models.
Identification of MRTX1133, a Noncovalent, Potent, and ...
pubs.acs.org › doi › 10Dec 10, 2021 · KRASG12D, the most common oncogenic KRAS mutation, is a promising target for the treatment of solid tumors. However, when compared to KRASG12C, selective inhibition of KRASG12D presents a significant challenge due to the requirement of inhibitors to bind KRASG12D with high enough affinity to obviate the need for covalent interactions with the mutant KRAS protein. Here, we report the discovery ...