srch

01.09.2021 · In contrast, total synthesis of morphine (1) and codeine (2) was implemented starting from intermediate 23 (Scheme 2). Specifically, after converting 23 into dienol ether 16 (vide supra), directly subjecting the latter to column chromatography on silica gel resulted in the generation of enone 28 (70% yield from phenol 23 ) through keto-enol tautomerization and …

The total synthesis of (±)-hinckdentine A is described herein. A cyanide-catalyzed imino-Stetter reaction of the aldimine derived from ethyl 2-amino-3,5-dibromocinnamate and 5-bromo-2-nitrobenzaldehyde followed by oxidative rearrangement afforded a 2,2-disubstituted 3-indolinone derivative containing the carbon skeleton and all of the functional groups present in the natural …

07.06.2021 · In summary, we have developed a powerful, general strategy for the stereoselective total synthesis of the marine natural products erogorgiaene and the pseudopterosins. In the chirogenic opening step, we exploited a Co-catalyzed enantioselective hydrovinylation, thus demonstrating the practicality of this methodology in the context of total synthesis.

09.11.2021 · The asymmetric total synthesis of (–)-rossinone A, a meroterpene exhibiting a range of pharmacologically important biological activities, has been accomplished for the first time from geraniol by a concise eight-step sequence that involves the Horner–Wadsworth–Emmons reaction of an aldehyde derived from a geranylated hydroquinone intermediate with a chiral …

Herein, we describe a scalable and robust synthesis of (−)-disorazole C1 with high stereoselectivity ... Organic Letters ( IF 6.005 ) Pub Date : 2021-05-26 ...

04.01.2021 · First total synthesis of rhodexin A. Org. Lett. 13, 2698–2701 (2011). CAS PubMed Article PubMed Central Google Scholar 52.

Total Synthesis of Dysifragilones A and B and Dysidavarone C. Org Lett. 2021 Aug 30. doi: 10.1021/acs.orglett.1c02641. Online ahead of print.

21.05.2020 · After the first preliminary total synthesis of leontopodioside A, we envisioned that there are some points need to be improved. For example, (1) the yield of key aglycone 6 was low; (2) intermediate 9 was quite difficult to be isolated from the reaction mixture; (3) the yield of O-6 acylated glucoside 10 was low. Therefore, a more efficient strategy was developed and which …

11.10.2021 · Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acute ischemic events. Herein, we describe the total synthesis of Hi1a using …

https://doi.org/10.1021/acs.orglett.1c02599 ... Herein, we reported the first total synthesis of omphalic acid with high stereochemical ...

Total Synthesis of ent-Plagiochianin B. Org Lett. 2021 Feb 19;23(4):1243-1246. doi: 10.1021/acs.orglett.0c04219. Epub 2021 Jan 30.

Herein we describe the total synthesis and antimicrobial evaluation of a marine ... Chem., 14 September 2021 | https://doi.org/10.3389/fchem.2021.741290 ...

Kigoshi, Synthesis, 2017, 49, 2958–2970 CrossRef CAS . B. Kang, J. Mowat, T. Pinter and R. Britton, Org. Lett., 2009, 11 ...

Organic Letters, 05 Jul 2016, 18(14):3426-3429 ... A time economical 60 min total synthesis of (-)-oseltamivir was accomplished in a single reaction vessel ...

Populus euphratica (Salicaceae), known as “hero tree of the desert”, grows widely in the desert of Xinjiang and Inner Mongolia of China. In this study, populusene A, featuring a bicyclo[8.4.1]pentadecane carbon skeleton and an anti-Bredt bridgehead double bond, and populusin A were identified. It is interesting that the inhibition of inflammation-associated …

22.11.2017 · Asymmetric total syntheses of natural (+)-gonytolide C (4) was reported, 7 however synthesis of natural (+)-blennolide C (2) has not been reported yet. Moreover, these syntheses are target-oriented using γ-lactone derivatives and development of more flexible synthetic methods is expected toward synthesis of natural products as well as their derivatives.

Dec 31, 2021 ... pubs.rsc.org. Unified Total Synthesis of the Brevianamide Alkaloids Enabled by Chemical Investigations into their. ... J Org Chem/Org Lett.

Memory of chirality in bromoalkyne carbocyclization: applications in asymmetric total synthesis of hasubanan alkaloids. Org. Lett. 21, 292–295 ( ...